Brenda Blethyn (née Bottle; born 20 February 1946) is an English actress. Known for her character work and versatility, she is the recipient of various accolades, including a Golden Globe, a BAFTA, and a Cannes Film Festival Award, as well as nominations for two Academy Awards and two Primetime Emmys. She was appointed Officer of the Order of the British Empire (OBE) for services to drama in 2003.

Blethyn pursued an administrative career before enrolling at the Guildford School of Acting in her late 20s. She subsequently joined the Royal National Theatre, gaining attention for her performances in plays such as Benefactors (1984), for which she received a nomination for the Laurence Olivier Award for Actress of the Year in a New Play. She made her Broadway debut in the revival of the Marsha Norman play 'Night Mother (2004).

She made her feature film debut with a small part in Nicolas Roeg's The Witches (1990). She starred in the Mike Leigh film Secrets & Lies (1996), which earned her a Cannes Film Festival Award for Best Actress as well as a nomination for the Academy Award for Best Actress. She was also Oscar-nominated for her role in Little Voice (1998). Her other notable film credits include A River Runs Through It (1992), Girls' Night (1998), Saving Grace (2000), Lovely & Amazing (2001), Pumpkin (2002), A Way of Life (2004), Pride & Prejudice (2005), and Atonement (2007).

Blethyn made her screen debut in the Mike Leigh television film Grown-Ups (1980). She has since starred in the sitcoms Chance in a Million (1984–1986), The Labours of Erica (1989–1990), Outside Edge (1994–1996), and Kate & Koji (2020–2022). She received Primetime Emmy Award nominations playing Auguste van Pels in Anne Frank: The Whole Story (2001) and for her guest role in Law & Order: Special Victims Unit (2008). From 2011 to 2025 she starred in ITV crime drama series Vera portraying Detective Chief Inspector Vera Stanhope.