Cleopatra: Original Soundtrack Album is the soundtrack from the film of the same name, released by 20th Century Fox Records in 1963. The music of Cleopatra was composed and conducted by Alex North, and was recorded and produced in 1963.

It has been released several times, first as an original vinyl album, in 1963. Later, in 1997, it was released in CD format by Tsunami Records, in Germany, as a Limited Edition album. The most popular of the releases was the Deluxe Edition, or 2001 Varèse Sarabande Edition, released as a double CD in 2001.

Joseph L. Mankiewicz, the film's director, made the unusual gesture, for him, of contributing extensive liner notes for the 1963 Original Soundtrack Album. These notes provide a valuable elucidation of many points in Mankiewicz's conception of Cleopatra that are unrealized in the version of the film that was released. Ironically, it was Mankiewicz's son Christopher who recommended North after his enthusiasm for his great score for Spartacus (1960).

In 1964, Cleopatra: Original Soundtrack Album was nominated for the Academy Award for Best Music Score - Substantially Original, and for the Grammy Award for Best Background Score from a Motion Picture or Television, but on both occasions it lost to Tom Jones (1963).