The second-generation iPhone SE (also known as the iPhone SE 2 or the iPhone SE 2020) is a smartphone designed, developed, and marketed by Apple Inc. It is part of the 13th generation of the iPhone, alongside the iPhone 11 and 11 Pro/Pro Max models. Apple announced the second-generation iPhone SE on April 15, 2020, coinciding with the discontinuation of the iPhone 8 and 8 Plus. The iPhone SE succeeded the smaller and lighter first-generation iPhone SE. Pre-orders began on April 17, 2020, and the phone was subsequently released on April 24, 2020. It was released with a starting price of US$399, and positioned as a budget phone.

Following the pattern made by the first-generation iPhone SE (which shares the dimensions and form factor of the iPhone 5S, with the internal hardware of the iPhone 6S), the second-generation model shares the dimensions and form factor of the iPhone 8, while sharing selected internal hardware components from the iPhone 11 lineup, including the A13 Bionic system-on-chip (as opposed to the A11 Bionic system-on-chip found in the iPhone 8 series), which allows the phone to utilise the single Wide angle lens Portrait Mode, as on the iPhone XR. It also features the next generation Smart HDR-2 photos, which are marketed as being better than Smart HDR photos on the iPhone XS and iPhone XR.

The second-generation iPhone SE was the last iPhone to feature 3 GB of RAM, as well as no 5G support.