Joseph Anthony Musgrove (born December 4, 1992) is an American professional baseball pitcher for the San Diego Padres of Major League Baseball (MLB). He previously played in MLB for the Houston Astros and Pittsburgh Pirates.

Musgrove was born in El Cajon, California, and began participating in baseball tournaments at the age of seven. He broke out as a star pitcher and batter during his junior season at Grossmont High School, which he helped take to two state championship appearances. After being selected by the Blue Jays in the first round of the 2011 MLB Draft, Musgrove chose to forgo his previous commitment to play college baseball for San Diego State, instead signing with the team. Partway through the 2012 season, Musgrove was traded to the Astros as part of a massive ten-player swap. There, his minor league career faltered due to a series of injuries, and he did not advance past the Rookie League until 2014. He began to rise through the Astros' farm system in 2015, and made his major league debut the following year.

In 2017, Musgrove was part of the World Series-winning Astros team. That offseason, Musgrove was part of another massive trade between the Astros and the Pirates. He spent two years there before being traded to his hometown Padres. On April 9, 2021, Musgrove pitched the first no-hitter in the Padres' 52-year franchise history.