Japanese video game developer Sega's Yakuza media franchise, known as Ryū ga Gotoku (龍が如く, lit. "Like a Dragon") in its native Japan and other Asian territories, features an extensive cast of characters. This article describes notable characters who appear in the Yakuza main series video games and associated remasters or remakes, with characters sorted by organizations or groups according to the original works. The English-language adaptation equivalents are mentioned when available.

In the first three installments, the sole playable protagonist is Kazuma Kiryu, a former yakuza who after ten years of imprisonment deals with chaos emerging from the yakuza organization he was formerly affiliated with, the Tojo clan. Yakuza 4 introduces three playable protagonists in addition to Kiryu. Yakuza 5 continued this trend and features five playable protagonists including Haruka Sawamura, a ward of Kiryu's whose story arc is devoid of combat mechanics. The prequel installment Yakuza 0 featured two protagonists, Kiryu and recurring supporting character Goro Majima. Kiryu is the only playable character in Yakuza 6, while an additional story played from Majima's perspective was added to the remake of Yakuza 2, Yakuza Kiwami 2. The 2 most recent mainline instalments , Yakuza: Like a Dragon and Like a Dragon: Infinite Wealth, features a new cast of characters. Players take control of a group of companions led by Ichiban Kasuga and the game introduces a new turn-based fighting style, opposed to the brawler free roam style of earlier instalments .