Melty Blood (メルティブラッド, Meruti Buraddo), sometimes shortened as Merubura (メルブラ), is a series of 2D visual novel fighting games, co-developed by dōjin circles Type-Moon and French-Bread as the meta-sequel of the Type-Moon's first visual novel Tsukihime. The first game was originally released at Comiket in December 2002, and later spawned multiple sequels, such as an arcade version titled Act Cadenza, developed by Ecole Software, which has also been ported to the PlayStation 2, the first Type-Moon title to receive a console release.

A manga series, written and illustrated by Takeru Kirishima, was first serialized in Kadokawa Shoten manga magazine Comp Ace in 2006. The series ended in 2011 with nine bound volumes released in Japan.

The latest title, called Melty Blood: Type Lumina, was released for Nintendo Switch, PlayStation 4, Xbox One and Microsoft Windows on September 30, 2021. It serves as a reboot of the series, and takes place in a new continuity first depicted in Tsukihime -A piece of blue glass moon-, a remake of the original Tsukihime.