The murder of Scott Amedure occurred on March 9, 1995, at his mobile home in Lake Orion, Michigan. The 32-year-old was killed by 24-year-old Jonathan Schmitz, three days after the men appeared as guests for the taping of an episode of the tabloid talk show The Jenny Jones Show. Amedure had publicly revealed in the episode that he had a crush on Schmitz, who claimed that he was straight but flattered by the revelation. On the morning of March 9, Amedure left a sexually suggestive note on Schmitz's apartment doorstep. In response, Schmitz purchased a 12-gauge shotgun, confronted Amedure at his home, and fired two shots into Amedure's chest. Schmitz called 911 to report the killing and he was subsequently arrested.

Schmitz was charged with first-degree murder. He utilized the gay panic defense, in which he claimed that he killed Amedure over embarrassment about the revelation of a same-sex crush. Schmitz was found guilty of second-degree murder.

The Amedure family sued The Jenny Jones Show for wrongful death, although the show was ultimately found to not be liable. Amedure and Schmitz's appearance on The Jenny Jones Show was shelved, although it was later shown to jurors during the civil trial against The Jenny Jones Show.