Skylar Annette Neese (February 10, 1996 – July 6, 2012) was an American teenage girl who disappeared from her home in Star City, West Virginia, around midnight on July 6, 2012. Her body was found in January 2013, across the nearby state line, in Wayne Township, Greene County, Pennsylvania.

Neese was murdered by two of her high school best friends, Shelia Eddy and Rachel Shoaf. In January 2013, Shoaf confessed to authorities that she and Eddy planned and carried out Neese's murder. Shoaf pleaded guilty to second-degree murder on May 1, 2013, and was sentenced to 30 years in prison with eligibility for parole after 10 years. Eddy pleaded guilty to first-degree murder on January 24, 2014, and was sentenced to life in prison with eligibility for parole after 15 years. Neese's disappearance led to new West Virginia legislation that made changes to the AMBER Alert missing child alert system.