The Panama national football team (Spanish: Selección de fútbol de Panamá) represents Panama in men's international football and is governed by the Federación Panameña de Fútbol (English: Panamanian Football Federation). Affiliated with FIFA since 1938, founding member of CONCACAF since 1961, and regionally affiliated with UNCAF. It was also a member of CCCF, which was the former governing body of football in Central America and Caribbean and a predeccessor confederation of CONCACAF, from 1938 to 1961.

Panama qualified for the FIFA World Cup for the first time for the 2018 tournament in Russia and scored their first goal of the World Cup against England, although they lost the match 6–1. They finished bottom of their group.

Panama finished as runners-up three times in the CONCACAF Gold Cup (2005, 2013 and 2023), and also runners-up in the CONCACAF Nations League in the 2025 finals. Regionally, Panama won the CCCF Championship as hosts in 1951 (organized by CCCF, the former confederation for the Central American and Caribbean zones), it also won the Copa Centroamericana in 2009 (organized by UNCAF), beating Costa Rica in the final (0–0 on full-time, 5–3 on penalties).