Reginald Alfred Bush III (born March 2, 1985) is an American former professional football running back. He played college football for the USC Trojans, earning consensus All-American honors twice and winning the 2005 Heisman Trophy. Bush is widely regarded as one of the greatest college football players of all time. He was selected by the New Orleans Saints second overall in the 2006 NFL draft. Bush was named an All-Pro punt returner in 2008 and won Super Bowl XLIV in 2010 with the Saints. He also played for the Buffalo Bills, Miami Dolphins, Detroit Lions, and San Francisco 49ers before retiring from professional football in 2017. Bush later worked a college football analyst for Fox Sports.

Allegations that he received improper benefits with USC in 2004 were central to an NCAA investigation of the USC football program that led to severe sanctions against the school, including a two-year postseason ban and the vacating of the 2004 national championship. Bush voluntarily forfeited his Heisman Trophy in 2010 amid the scandal, but it was reinstated 14 years later amid NCAA rule changes.