"The 100 Greatest Artists of All Time" is a special issue published by Rolling Stone in two parts in 2004 and 2005, and later updated in 2011. The list presented was compiled based on input from musicians, writers, and industry figures and is focused on the rock & roll era.

The publication features comments that several musicians wrote about their colleagues, including Elvis Costello on the Beatles, Janet Jackson on Tina Turner, and others.

Since its publication, the list has been frequently cited by many specialized and generalist publications.