Take-Two Interactive Software, Inc. is an American video game holding company based in New York City founded by Ryan Brant in September 1993.

The company owns three major publishing labels, Rockstar Games, Zynga and 2K, which operate internal game development studios. Take-Two created the Private Division label to support publishing from independent developers, though it sold the label in 2024. The company also formed Ghost Story Games which was a former 2K studio under the name Irrational Games. The company acquired the developers Socialpoint, Playdots and Nordeus to establish itself in the mobile game market. The company also owns 50% of professional esports organization NBA 2K League through NBA Take-Two Media. Take-Two's combined portfolio includes franchises such as BioShock, Borderlands, Civilization, Grand Theft Auto, NBA 2K, WWE 2K, and Red Dead among others.

As of April 2025, it is one of the largest publicly traded game companies globally with an estimated market cap of US$41 billion.